An Evaluation of Three-Dimensional Modeling of Compaction Cycles by Analyzing the Densification Behavior of Binary and Ternary Mixtures
- 1 January 2001
- journal article
- research article
- Published by Taylor & Francis Ltd in Pharmaceutical Development and Technology
- Vol. 6 (3), 333-342
- https://doi.org/10.1081/pdt-100002615
Abstract
The aim of the study is to use the 3D modeling technique of compaction cycles for analysis of binary and ternary mixtures. Three materials with very different deformation and densification characteristics [cellulose acetate (CAC), dicalcium phosphate dihydrate (EM) and theophylline monohydrate (TM)] have been tableted at graded maximum relative densities (ρrel, max) on an eccentric tableting machine. Following that, graded binary mixtures from CAC and EM have been compacted. Finally, the same ratios of CAC and EM have been tableted in a ternary mixture with 20 vol% TM. All compaction cycles have been analyzed by using different data analysis methods. Three-dimensional modeling, conventional determination of the slope of the Heckel function, determination of the elastic recovery during decompression, and calculations according to the pressure–time function were the methods of choice. The results show that the 3D model technique is able to gain the information in one step instead of three different approaches, which is an advantage for formulation development. The results show that this model enables one to better distinguish the compaction properties of mixtures and the interaction of the components in the tablet than 2D models. Furthermore, the information by 3D modeling is more precise since in the slope K of the Heckel-plot (in die) elasticity is included, and in the parameters of the pressure–time function β and γ plastic deformation due to pressure is included. The influence of time and pressure on the displacement can now be differentiated.Keywords
This publication has 15 references indexed in Scilit:
- A new theoretical approach to tablet strength of a binary mixture consisting of a well and a poorly compactable substanceEuropean Journal of Pharmaceutics and Biopharmaceutics, 2000
- A New Method to Evaluate the Consolidation Behavior of Pharmaceutical Materials by Using the Fraser–Suzuki FunctionDrug Development and Industrial Pharmacy, 1999
- Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed productionEuropean Journal of Pharmaceutics and Biopharmaceutics, 1998
- Effect of Relative Humidity During Tabletting on Matrix Formation of Hydrocolloids: Densification Behavior of Cellulose EthersPharmaceutical Development and Technology, 1998
- Compression force/time-profiles of microcrystalline cellulose, dicalcium phosphate dihydrate and their binary mixtures—a critical consideration of experimental parametersEuropean Journal of Pharmaceutics and Biopharmaceutics, 1997
- Force-Time-Curves of a Modern Rotary Tablet Machine I. Evaluation Techniques and Characterization of Deformation Behaviour of Pharmaceutical SubstancesDrug Development and Industrial Pharmacy, 1994
- Prediction of the compression behaviour of powder mixtures by the Heckel equationInternational Journal of Pharmaceutics, 1993
- Compaction Properties of Acrylic Resin Polymers with Plastic and Brittle DrugsDrug Development and Industrial Pharmacy, 1990
- Compression characteristics of pharmaceutical powder mixturesPowder Technology, 1978
- The influence of the moisture content of the fibrous support of a nasal inhaler upon the concentration of drug in the air streamJournal of Pharmacy and Pharmacology, 1972