Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
Open Access
- 1 January 2007
- journal article
- review article
- Published by The Korean Society of Electrolyte Metabolism in Electrolytes & Blood Pressure
- Vol. 5 (1), 15-22
- https://doi.org/10.5049/ebp.2007.5.1.15
Abstract
Vasopressin, angiotensin II (AngII), and aldosterone are essential hormones in the regulation of body fluid homeostatsis. We examined the effects of AngII or aldosterone on the regulation of body water balance. We demonstrated that 1) short-term treatment with AngII in the primary cultured inner medullary collecting duct cells played a role in the regulation of AQP2 targeting to the plasma membrane through AT1 receptor activation. This potentiated the effects of dDAVP on cAMP accumulation, AQP2 phosphorylation, and AQP2 plasma membrane targeting; 2) pharmacological blockade of the AngII AT1 receptor in rats co-treated with dDAVP and dietary NaCl-restriction (to induce high plasma endogenous AngII) resulted in an increase in urine production, a decrease in urine osmolality, and blunted the dDAVP-induced upregulation of AQP2; 3) long-term aldosterone infusion in normal rats or in rats with diabetes insipidus was associated with polyuria and decreased urine concentration, accompanied by decreased apical but increased basolateral AQP2 labeling intensity in the connecting tubule and cortical collecting duct; and 4) in contrast to the effects of dDAVP and AngII, short-term aldosterone treatment does not alter the intracellular distribution of AQP2. In conclusion, angiotensin II, and aldosterone could play a role in the regulation of renal water reabsorption by changing intracellular AQP2 targeting and/or AQP2 abundance, in addition to the vasopressin.Keywords
This publication has 38 references indexed in Scilit:
- Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1receptorAmerican Journal of Physiology-Renal Physiology, 2007
- Lithium-induced NDI in rats is associated with loss of α-ENaC regulation by aldosterone in CCDAmerican Journal of Physiology-Renal Physiology, 2006
- Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidusAmerican Journal of Physiology-Renal Physiology, 2006
- Angiotensin II AT1receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted ratsAmerican Journal of Physiology-Renal Physiology, 2005
- Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limbKidney International, 2002
- Coupling of vasopressin‐induced intracellular Ca2+ mobilization and apical exocytosis in perfused rat kidney collecting ductThe Journal of Physiology, 2002
- Physiology and pathophysiology of renal aquaporinsSeminars in Nephrology, 2001
- Regulation of Aquaporin-2 Trafficking by Vasopressin in the Renal Collecting DuctJournal of Biological Chemistry, 2000
- Cloning and expression of apical membrane water channel of rat kidney collecting tubuleNature, 1993
- Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct.JCI Insight, 1988