The fat mass–and obesity-associated locus and dietary intake in children
Open Access
- 1 October 2008
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 88 (4), 971-978
- https://doi.org/10.1093/ajcn/88.4.971
Abstract
Background: A region of chromosome 16 containing the fat mass–and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity. Objectives: We aimed to assess the possibility that appetite plays a role in the association between FTO and BMI. Design: Detailed dietary report information from the Avon Longitudinal Study of Parents and Children allowed the exploration of relations between FTO variation and dietary intake. Analyses were performed to investigate possible associations between variation at the FTO locus and the intake of a range of micronutrients and macronutrients, with adjustment for the bias often found within dietary report data when factors related to BMI are assessed. To test the hypothesis that FTO may be influencing appetite directly, rather than indirectly via BMI and altered intake requirements, we also assessed associations between FTO and dietary intake independent of BMI. Results: Relations between a single-nucleotide polymorphism characterizing the FTO signal (rs9939609) and dietary variables were found and can be summarized by the effect of each additional allele (per-allele effects) on total energy and total fat (P < 0.001 for both). These associations were attenuated, but they persisted specifically for fat and energy consumption after adjustment for BMI [total daily fat consumption: ≈1.5 g/d (P = 0.02 for the per-allele difference); total daily energy consumption: ≈25 kJ/d (P = 0.03 for the per-allele difference)]. Conclusion: These associations suggest that persons carrying minor variants at rs9939609 were consuming more fat and total energy than were those not carrying such variants. They also suggest that this difference was not simply dependent on having higher average BMIs among the former group.Keywords
This publication has 24 references indexed in Scilit:
- Regulation ofFto/Ftmgene expression in mice and humansAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- The Obesity-AssociatedFTOGene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid DemethylaseScience, 2007
- A prospective analysis of dietary energy density at age 5 and 7 years and fatness at 9 years among UK childrenInternational Journal of Obesity, 2007
- Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 2007
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007
- Defects in brain patterning and head morphogenesis in the mouse mutant Fused toesDevelopmental Biology, 2007
- Obesity and the Environment: Where Do We Go from Here?Science, 2003
- ALSPAC–The Avon Longitudinal Study of Parents and ChildrenPaediatric and Perinatal Epidemiology, 2001
- Associations between dietary intakes and blood cholesterol concentrations at 31 monthsEuropean Journal of Clinical Nutrition, 2001
- Activity, Dietary Intake, and Weight Changes in a Longitudinal Study of Preadolescent and Adolescent Boys and GirlsPediatrics, 2000