Biological Evaluation of Some Selected Plant Species of Pakistan

Abstract

Seven methanol extracts from five different plant species [Salvia nubicola. B. (Laminiaceae), Acer oblongifolium. D. (Aceraceae), Sorbaria tomentosa. L. (Rosaceae), Hedera nepalensis. K. (Araliaceae), and Artemisia fragrans. W. (Asteraceae)] were evaluated for brine shrimp cytotoxicity, antitumor potato disc, and radish seed phytotoxicity activity. Four of the seven extracts revealed significant ED₅₀ value ranging from 11.9 to 226.8 ppm. Inhibition of tumor formation ranged from 9 to 82.9% by all extracts in antitumor potato disc assay at three different concentrations tested (1000, 100, and 10 ppm). Growth inhibition was observed by all extracts in radish seed bioassay at high concentration (10,000 ppm). At low concentration (1000 ppm), three extracts from two plant species (leaf and flower extract of S. nubicola., stem extract of S. nubicola., and stem extract of H. nepalensis.) presented stimulation of growth ranging from 3.5 to 43.2%. A positive correlation was observed in the results of three of the described assays.