Factors for progression and glaucoma treatment: The Early Manifest Glaucoma Trial
- 1 April 2004
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Opthalmology
- Vol. 15 (2), 102-106
- https://doi.org/10.1097/00055735-200404000-00008
Abstract
This review summarizes factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of treatment. EMGT randomized patients with early glaucoma either to argon laser trabeculoplasty plus betaxolol (n = 129) or to no immediate treatment (n = 126) and followed them every 3 months. Treated patients had delayed progression, as compared with controls. In Cox regression, EMGT treatment halved the risk of progression (hazard ratio = 0.50; 95% confidence interval: 0.35, 0.71). Risk decreased about 10% with each millimeter mercury of intraocular pressure (IOP) reduction from baseline; the higher (or lower) the IOP at follow-up, the higher (or lower) the risk. Baseline factors increasing progression were higher IOP, exfoliation, bilateral disease, worse perimetric mean deviation and older age; frequent disc hemorrhages at follow-up also increased risk. EMGT treatment reduced progression risk in half, demonstrating the value of IOP lowering in early glaucoma. Age and indicators of disease severity also predicted progression.Keywords
This publication has 16 references indexed in Scilit:
- The Ocular Hypertension Treatment StudyAmerican Journal of Ophthalmology, 2002
- The Ocular Hypertension Treatment StudyAmerican Journal of Ophthalmology, 2002
- Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgeryOphthalmology, 2001
- The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deteriorationAmerican Journal of Ophthalmology, 2000
- Early manifest glaucoma trialOphthalmology, 1999
- The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucomaAmerican Journal of Ophthalmology, 1998
- Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressuresAmerican Journal of Ophthalmology, 1998
- The Glaucoma Laser Trial (GLT)Ophthalmology, 1990
- DISC HAEMORRHAGE AND GLAUCOMAActa Ophthalmologica, 1981