Autophagy in cellular growth control
Open Access
- 22 January 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (7), 1417-1426
- https://doi.org/10.1016/j.febslet.2010.01.009
Abstract
Cell growth is regulated by two antagonistic processes: TOR signaling and autophagy. These processes integrate signals including growth factors, amino acids, and energy status to ensure that cell growth is appropriate to environmental conditions. Autophagy responds indirectly to the cellular milieu as a downstream inhibitory target of TOR signaling and is also directly controlled by nutrient availability, cellular energy status, and cell stress. The control of cell growth by TOR signaling and autophagy are relevant to disease, as altered regulation of either pathway results in tumorigenesis. Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis.Funding Information
- NIH (RO1 CA84254, ROI CA109618)
This publication has 110 references indexed in Scilit:
- Control of autophagy initiation by phosphoinositide 3-phosphatase jumpyThe EMBO Journal, 2009
- Nutrient control of TORC1, a cell-cycle regulatorTrends in Cell Biology, 2009
- Autophagy Suppresses Tumorigenesis through Elimination of p62Cell, 2009
- A Role for Ubiquitin in Selective AutophagyMolecular Cell, 2009
- JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced AutophagyMolecular Cell, 2008
- p53: The Janus of autophagy?Nature, 2008
- AMPK Phosphorylation of Raptor Mediates a Metabolic CheckpointMolecular Cell, 2008
- Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2Molecular Cell, 2007
- Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell DeathCurrent Biology, 2007
- Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat BodyDevelopmental Cell, 2004