Serum and placental interleukin-18 are elevated in preeclampsia
- 1 February 2005
- journal article
- Published by Elsevier BV in Journal of Reproductive Immunology
- Vol. 65 (1), 77-87
- https://doi.org/10.1016/j.jri.2004.09.003
Abstract
Interleukin-18 (IL-18) is a proinflammatory cytokine with pleiotrophic qualities and its roles in pregnancy, labor onset and pregnant complications have been proposed. However, the alterations of serum and placental IL-18 have been less investigated. The objective of the current investigation was to detect IL-18 concentrations in serum and placentas from patients with preeclampsia and women with normal pregnancy. 27 patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placental samples were taken and IL-18 concentrations in serum and placental homogenate were analyzed by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared between preeclampsia and control. Both serum and placental levels of IL-18 were significantly increased in preeclampsia as compared with control (P=0.014 and 0.003, respectively). Serum and placental levels of IL-18 were not significantly different in preeclamptic women who received dexomethasone and those who did not (P=0.223 and 0.330, respectively). Serum and placental IL-18 levels were not significantly different between preeclamptic women who delivered before 36 complete gestational weeks and those who delivered after 36 complete weeks (P=0.616 and 0.869, respectively). There were no significant differences in serum and placental IL-18 between women with mild preeclampsia and those with severe preeclampsia (P=0.056 and 0.357, respectively). Increased serum and placental levels of IL-18 were observed in preeclampsia. Those associations may offer insight into the pathogenesis of the disease.Keywords
This publication has 29 references indexed in Scilit:
- IL‐18 is Present at the Maternal–Fetal Interface and Enhances Cytotoxic Activity of Decidual LymphocytesAmerican Journal of Reproductive Immunology, 2002
- Expression of Inflammatory Cytokines in Placentas from Women with PreeclampsiaJournal of Clinical Endocrinology & Metabolism, 2001
- Evidence for an Elevation in Serum Interleukin-2 and Tumor Necrosis Factor-α Levels Before the Clinical Manifestations of PreeclampsiaAmerican Journal of Reproductive Immunology, 1997
- Pregnancy-related mortality in the united states, 1987–1990Obstetrics & Gynecology, 1996
- Cloning of a new cytokine that induces IFN-γ production by T cellsNature, 1995
- Plasma type II phospholipase A2 levels are elevated in severe preeclampsiaAmerican Journal of Obstetrics and Gynecology, 1995
- Interleukin‐6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre‐eclampsiaBJOG: An International Journal of Obstetrics and Gynaecology, 1995
- Abnormal Hemostasis and Coagulopathy in Preeclampsia and EclampsiaClinical Obstetrics and Gynecology, 1992
- Neutrophil activation in pregnancy‐induced hypertensionBJOG: An International Journal of Obstetrics and Gynaecology, 1989
- Enhanced platelet release reaction related to arterial plasma adrenaline and blood pressure in pre‐eclampsiaBJOG: An International Journal of Obstetrics and Gynaecology, 1986