SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
Top Cited Papers
- 17 June 2011
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 332 (6036), 1443-1446
- https://doi.org/10.1126/science.1202723
Abstract
Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for SIRT6 exhibit genome instability. Here, we show that in mammalian cells subjected to oxidative stress SIRT6 is recruited to the sites of DNA double-strand breaks (DSBs) and stimulates DSB repair, through both nonhomologous end joining and homologous recombination. Our results indicate that SIRT6 physically associates with poly[adenosine diphosphate (ADP)–ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimulating PARP1 poly-ADP-ribosylase activity and enhancing DSB repair under oxidative stress.Keywords
This publication has 36 references indexed in Scilit:
- RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP DeacetylationScience, 2010
- Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6Cell Cycle, 2009
- The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stabilityCell Cycle, 2009
- Stress Response and AgingScience, 2009
- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repairAging, 2009
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinNature, 2008
- Involvement of Polynucleotide Kinase in a Poly(ADP-ribose) Polymerase-1-dependent DNA Double-strand Breaks Rejoining PathwayJournal of Molecular Biology, 2006
- Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6Cell, 2006
- Making ends meet in old age: DSB repair and agingMechanisms of Ageing and Development, 2005
- Poly(ADP-ribosyl)ation: a posttranslational proteinmodification linked with genome protection andmammalian longevityBiogerontology, 2000