Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
Open Access
- 7 June 2010
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 189 (6), 1013-1025
- https://doi.org/10.1083/jcb.201001057
Abstract
Kinesin-2 motor KIF17 autoinhibition is visualized in vivo; in the absence of cargo, this homodimer’s C-terminal tail blocks microtubule binding, and a coiled-coil segment blocks motility.Keywords
This publication has 24 references indexed in Scilit:
- Kinesin superfamily motor proteins and intracellular transportNature Reviews Molecular Cell Biology, 2009
- Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of AutoinhibitionPLoS Biology, 2009
- The kinesin-1 motor protein is regulated by a direct interaction of its head and tailProceedings of the National Academy of Sciences of the United States of America, 2008
- The Effector Domain of Human Dlg Tumor Suppressor Acts as a Switch That Relieves Autoinhibition of Kinesin-3 Motor GAKIN/KIF13BBiochemistry, 2007
- Tracking Single Kinesin Molecules in the Cytoplasm of Mammalian CellsBiophysical Journal, 2007
- NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteinsNucleic Acids Research, 2007
- Two binding partners cooperate to activate the molecular motor Kinesin-1The Journal of cell biology, 2007
- Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cellsThe Journal of cell biology, 2007
- Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3The Journal of cell biology, 2006
- Review: regulation mechanisms of Kinesin-1Journal of Muscle Research and Cell Motility, 2006