Serum ferritin concentration in sickle cell crisis.
Open Access
- 1 March 1986
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 39 (3), 253-255
- https://doi.org/10.1136/jcp.39.3.253
Abstract
Serum ferritin, aspartate aminotransferase (AST), alkaline phosphatase and hydroxybutyrate dehydrogenase (HBD) were studied during 21 vaso-occlusive crises in 12 adults with sickle cell disease (11 SS, 1 S beta degrees). The patients comprised three groups: those who had been untransfused (4), those who had received occasional exchange transfusion in crisis (3), and those who had been multiply transfused (5). Serum ferritin concentrations in crisis were compared with those of the steady state value. Rises in serum ferritin concentrations occurred in all crises in all groups. Although AST, alkaline phosphatase, and HBD rose, there was no correlation between these and log ferritin concentrations. The clinical impression was that the degree of rise in ferritin related to the severity of the particular crisis, and the above results showed that haemolysis and liver damage were not causally related to this rise. An estimate of serum ferritin cannot be used to assess the state of iron balance in sickle cell disease unless the patient is in the steady state. The considerable rise in serum ferritin concentration found in crisis, however, may be a useful marker of the extent of vaso-occlusion and tissue damage.Keywords
This publication has 10 references indexed in Scilit:
- Effect of blood transfusion on iron status in sickle cell anaemiaClinical and Laboratory Haematology, 1984
- IRON STORES IN ADULTS WITH SICKLE-CELL-ANEMIA1984
- Iron deficiency in sickle cell anaemia.Journal of Clinical Pathology, 1983
- The diagnosis of iron deficiency anemia in sickle cell diseaseBlood, 1981
- Iron burden in sickle cell anemiaThe Journal of Pediatrics, 1978
- SERUM FERRITIN AND DYSBARIC OSTEONECROSIS1977
- Iron metabolism, sickle cell disease, and response to cyanate.1975
- Iron metabolism, sickle cell disease, and response to cyanateBlood, 1975
- An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overloadJournal of Clinical Pathology, 1972