Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine
Top Cited Papers
- 13 June 2014
- journal article
- review article
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET)
- Vol. 66 (3), 676-814
- https://doi.org/10.1124/pr.113.008268
Abstract
The large Trp gene family encodes transient receptor potential (TRP) proteins that form novel cation-selective ion channels. In mammals, 28 Trp channel genes have been identified. TRP proteins exhibit diverse permeation and gating properties and are involved in a plethora of physiologic functions with a strong impact on cellular sensing and signaling pathways. Indeed, mutations in human genes encoding TRP channels, the so-called “TRP channelopathies,” are responsible for a number of hereditary diseases that affect the musculoskeletal, cardiovascular, genitourinary, and nervous systems. This review gives an overview of the functional properties of mammalian TRP channels, describes their roles in acquired and hereditary diseases, and discusses their potential as drug targets for therapeutic intervention.Keywords
This publication has 99 references indexed in Scilit:
- Pairing phosphoinositides with calcium ions in endolysosomal dynamicsBioEssays, 2011
- Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosumDevelopmental Neurobiology, 2011
- Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell deathCellular and Molecular Life Sciences, 2010
- Dominant TRPV4 Mutations in Nonlethal and Lethal Metatropic DysplasiaAmerican Journal of Medical Genetics Part A, 2010
- Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomasGlia, 2010
- TRPC5 channels undergo changes in gating properties during the activation-deactivation cycleJournal of Cellular Physiology, 2008
- Insulin and insulin‐like growth factor type‐I up‐regulate the vanilloid receptor‐1 (TRPV1) in stably TRPV1‐expressing SH‐SY5Y neuroblastoma cellsJournal of Neuroscience Research, 2007
- Immunoreactivity of VR1 on Epidermal Keratinocyte of Human SkinBiochemical and Biophysical Research Communications, 2001
- Resistance to Aging‐Associated Obesity in Capsaicin‐Desensitized Rats One Year after TreatmentObesity Research, 1995
- Weight loss induced by gastric implant in ratsDigestive Diseases and Sciences, 1992