Pathogenic characteristics of persistent feline enteric coronavirus infection in cats
Open Access
- 23 July 2010
- journal article
- Published by EDP Sciences in Veterinary Research
- Vol. 41 (5), 71
- https://doi.org/10.1051/vetres/2010043
Abstract
Feline coronaviruses (FCoV) comprise two biotypes: feline enteric coronaviruses (FECV) and feline infectious peritonitis viruses (FIPV). FECV is associated with asymptomatic persistent enteric infections, while FIPV causes feline infectious peritonitis (FIP), a usually fatal systemic disease in domestic cats and some wild Felidae. FIPV arises from FECV by mutation. FCoV also occur in two serotypes, I and II, of which the serotype I viruses are by far the most prevalent in the field. Yet, most of our knowledge about FCoV infections relates to serotype II viruses, particularly about the FIPV, mainly because type I viruses grow poorly in cell culture. Hence, the aim of the present work was the detailed study of the epidemiologically most relevant viruses, the avirulent serotype I viruses. Kittens were inoculated oronasally with different doses of two independent FECV field strains, UCD and RM. Persistent infection could be reproducibly established. The patterns of clinical symptoms, faecal virus shedding and seroconversion were monitored for up to 10 weeks revealing subtle but reproducible differences between the two viruses. Faecal virus, i.e. genomic RNA, was detected during persistent FECV infection only in the large intestine, downstream of the appendix, and could occasionally be observed also in the blood. The implications of our results, particularly our insights into the persistently infected state, are discussed.Keywords
This publication has 34 references indexed in Scilit:
- Sites of feline coronavirus persistence in healthy catsJournal of General Virology, 2010
- Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c geneJournal of General Virology, 2009
- A review of feline infectious peritonitis virus infection: 1963–2008Journal of Feline Medicine and Surgery, 2009
- Pathogenesis of feline enteric coronavirus infectionJournal of Feline Medicine and Surgery, 2008
- Natural feline coronavirus infection: Differences in cytokine patterns in association with the outcome of infectionVeterinary Immunology and Immunopathology, 2006
- Acquisition of Macrophage Tropism during the Pathogenesis of Feline Infectious Peritonitis Is Determined by Mutations in the Feline Coronavirus Spike ProteinJournal of Virology, 2005
- Replication of feline coronaviruses in peripheral blood monocytesArchiv für die gesamte Virusforschung, 2005
- High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected catsJournal of Feline Medicine and Surgery, 2004
- A study of naturally occurring feline coronavirus infections in kittensVeterinary Record, 1992
- Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronavirusesArchiv für die gesamte Virusforschung, 1991