Numerical Simulation of the Effects of Dilution Level, Depth of Inhalation, and Smoke Composition on Nicotine Vapor Deposition During Cigarette Smoking
- 1 January 2006
- journal article
- research article
- Published by Informa UK Limited in Inhalation Toxicology
- Vol. 18 (14), 1071-1076
- https://doi.org/10.1080/08958370600945457
Abstract
A numerical model of an aerosol containing vaporizable nicotine depositing to the walls of a tube was developed and applied to simulate the vapor deposition of nicotine in a denuder tube and under conditions approximating those in the respiratory tract during mainstream cigarette smoke inhalation. The numerical model was validated by comparison to data for denuder tube collection of nicotine from the smoke of three types of cigarette differing in smoke acidity and nicotine volatility. Simulations predict that the absorption of water by aerosol particles inhibits nicotine vapor deposition to tube walls, and that increased temperature, decreased tube diameter, and increased dilution enhance nicotine vapor deposition rate. The combined effect of changing these four parameters to approximate the transition from conducting to gas exchange regions of the respiratory tract was a significant net increase in predicted nicotine vapor deposition rate. Comparisons of nicotine deposition rates between conditions in the conducting airways and those in the gas exchange region were informative with regard to reported nicotine retention measurements during human smoking. Reports that vaporizable nicotine can penetrate past the conducting airways, that nicotine can be retained at near 100% efficiency from mainstream smoke, and that cigarettes with differing acidity and nicotine volatility have similar nicotine uptake rates are all shown to be consistent with the results of the model simulations.Keywords
This publication has 10 references indexed in Scilit:
- The Retention of Tobacco Smoke Constituents in the Human Respiratory TractInhalation Toxicology, 2006
- On the Deposition of Volatiles and Semivolatiles from Cigarette Smoke Aerosols: Relative Rates of Transfer of Nicotine and Ammonia from Particles to the Gas PhaseChemical Research in Toxicology, 2004
- Evaporation and subsequent deposition of nicotine from mainstream cigarette smoke in a denuder tubeJournal of Aerosol Science, 2004
- A Review of the Influence of Particle Size, Puff Volume, and Inhalation Pattern on the Deposition of Cigarette Smoke Particles in the Respiratory TractInhalation Toxicology, 2004
- A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory TractChemical Research in Toxicology, 2001
- Deposition of Cigarette Smoke Particles in the Human Respiratory TractAerosol Science and Technology, 2001
- Particle-Gas Equilibria of Ammonia and Nicotine in Mainstream Cigarette SmokeAerosol Science and Technology, 2001
- Dilution of mainstream tobacco smoke and its effects upon the evaporation and diffusion of nicotineJournal of Aerosol Science, 1995
- Regional deposition of inhaled 11C-nicotine vapor in the human airway as visualized by positron emission tomography*Clinical Pharmacology & Therapeutics, 1995
- Nicotine, resorption and fatePharmacology & Therapeutics, 1982