C-erbB-2 Immunostaining in Laryngeal Cancer
- 1 January 1999
- journal article
- research article
- Published by Informa UK Limited in Acta Oto-Laryngologica
- Vol. 119 (3), 392-395
- https://doi.org/10.1080/00016489950181440
Abstract
Tumour progression is strongly associated with a series of specific genetic changes in protooncogenes and tumour suppressor genes. One of the potential factors involved in tumorogenesis of squamous cell carcinomas is protooncogene c-erbB-2 (also known as neu or HER2). The authors analysed the expression of c-erbB-2 oncoprotein in 154 cases of laryngeal squamous cell carcinomas and its relationship to the clinical outcome of the patients. The difference in c-erbB-2 oncoprotein expression between the control group and cancer patients was on the statistical borderline (p=0.0470). There was no significant correlation between c-erbB-2 expression and sex and age of the patients, T stage, lymph node status, site and histopathological grading of the tumour and clinical outcome of the patients. Univariate analysis revealed no correlation between c-erbB-2 expression and survival rates. We conclude that immunohistological examination of c-erbB-2 on paraffin section is not a valuable prognostic factor in laryngeal carcinoma.Keywords
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