Structure-Activity Relationships for Non-Steroidal Inhibitors of Aromatase
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Enzyme Inhibition
- Vol. 2 (3), 215-229
- https://doi.org/10.3109/14756368809040728
Abstract
A model is described for the binding of non-steroidal inhibitors of aromatase to the enzyme with interaction of a ligand with the Fe3+-haem of the cytochrome. The model suggests that the inhibitors utilise a common binding site with ring A of the steroidal substrates.Keywords
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