Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community

Abstract

Aims To evaluate the association of serum phosphorus with cardiac structure/function and incident heart failure. Methods and results We related serum phosphorus to echocardiographic left ventricular (LV) measurements cross‐sectionally, and to incident heart failure prospectively in 3300 participants (mean age 44 years, 51% women) free of heart failure, myocardial infarction, and chronic kidney disease (estimated glomerular filtration rate [eGFR]90 mL/min/1.73 m², no proteinuria and serum phosphorus <4.5 mg/dL, the association of serum phosphorus with heart failure remained robust. Conclusion In our community‐based sample, higher serum phosphorus was associated with greater LV mass cross‐sectionally, and with an increased risk of heart failure prospectively.