An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood
- 31 October 2008
- journal article
- Published by Elsevier BV in Personality and Individual Differences
- Vol. 45 (5), 425-428
- https://doi.org/10.1016/j.paid.2008.05.020
Abstract
Although a vast literature examining the role of attributional styles in depression has accumulated, the origins of such cognitions remain poorly understood. Investigators are increasingly interested in whether cognitive vulnerability to depression is linked to genetic variation. As a preliminary test of this hypothesis, we examined whether the serotonin transporter promoter polymorphism (5-HTTLPR) was associated with attributional styles in children. Thirty-eight children completed a self-report measure of attributional styles, the Child Attributional Style Questionnaire-Revised (CASQ-R). Children were also genotyped for the 5-HTTLPR polymorphism, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR. The short alleles of the 5-HTTLPR and their putative functional equivalents were associated with increased levels of depressogenic attributions for negative events, as measured by the CASQ-R, lending support to the role of 5-HTTLPR polymorphisms in cognitive vulnerability to depression.Keywords
This publication has 32 references indexed in Scilit:
- Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphismJournal of Affective Disorders, 2008
- Stability of laboratory-assessed temperamental emotionality traits from ages 3 to 7.Emotion, 2007
- Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive DisorderAmerican Journal of Human Genetics, 2006
- Positive emotionality at age 3 predicts cognitive styles in 7-year-old childrenDevelopment and Psychopathology, 2006
- Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto × Fisher 344 crossMolecular Psychiatry, 2003
- Inherited Hypohedonia Leads to Learned Helplessness: A Conjecture UpdatedReview of General Psychology, 1998
- Models of cognitive mediation and moderation in child depression.Journal of Abnormal Psychology, 1993
- Attributional style as a vulnerability factor for depression: Validation by past history of mood disordersCognitive Therapy and Research, 1992
- THE VALIDITY OF DEPRESSIVE DISORDER IN CHILDHOOD AND THE DEVELOPMENT OF A SELF‐RATING SCALE: A RESEARCH REPORTJournal of Child Psychology and Psychiatry, 1981
- Learned helplessness in humans: Critique and reformulation.Journal of Abnormal Psychology, 1978