Pharmacogenomics Knowledge for Personalized Medicine
Top Cited Papers
- 1 October 2012
- journal article
- review article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 92 (4), 414-417
- https://doi.org/10.1038/clpt.2012.96
Abstract
The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene–drug associations and genotype–phenotype relationships. Curators assign levels of evidence to variant–drug associations using well‐defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high‐quality information supporting personalized medicine–implementation projects. Clinical Pharmacology & Therapeutics (2012); 92 4, 414–417. doi:10.1038/clpt.2012.96Keywords
This publication has 4 references indexed in Scilit:
- The 1200 Patients Project: Creating a New Medical Model System for Clinical Implementation of PharmacogenomicsClinical Pharmacology & Therapeutics, 2012
- Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping ArrayClinical Pharmacology & Therapeutics, 2012
- From Pharmacogenomic Knowledge Acquisition to Clinical Applications: The PharmGKB as a Clinical Pharmacogenomic Biomarker ResourceBiomarkers in Medicine, 2011
- CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research NetworkClinical Pharmacology & Therapeutics, 2011