In remembrance of things past: memory T cells and transplant rejection
- 10 November 2003
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 196 (1), 65-74
- https://doi.org/10.1046/j.1600-065x.2003.00087.x
Abstract
Summary: A cardinal feature of the adaptive immune response is its ability to generate long‐lived populations of memory T lymphocytes. Memory T cells are specific to the antigen encountered during the primary immune response and react rapidly and vigorously upon re‐encounter with the same antigen. Memory T cells that recognize microbial antigens provide the organism with long‐lasting protection against potentially fatal infections. On the other hand, memory T cells that recognize donor alloantigens can jeopardize the survival of life‐saving organ transplants. We review here the immunobiology of memory T cells and describe their role in the rejection of solid organ allografts.Keywords
This publication has 115 references indexed in Scilit:
- Lineage relationship and protective immunity of memory CD8 T cell subsetsNature Immunology, 2003
- Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T CellsThe Journal of Experimental Medicine, 2002
- Chemokines in rapid leukocyte adhesion triggering and migrationSeminars in Immunology, 2002
- Control of Homeostasis of CD8 + Memory T Cells by Opposing CytokinesScience, 2000
- PREVENTION OF RENAL ALLOGRAFT REJECTION IN PRIMATES BY BLOCKING THE B7/CD28 PATHWAY1Transplantation, 1999
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999
- Linear Differentiation of Cytotoxic Effectors into Memory T LymphocytesScience, 1999
- T CELL MEMORYAnnual Review of Immunology, 1998
- Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivityEuropean Journal of Immunology, 1997
- PREDOMINANT INFILTRATION OF REJECTING HUMAN RENAL ALLOGRAFTS WITH T CELLS EXPRESSING CD8 AND CD45ROTransplantation, 1995