Overexpression of Transforming Growth Factor α in Psoriatic Epidermis
- 10 February 1989
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4892), 811-814
- https://doi.org/10.1126/science.2916128
Abstract
Transforming growth factor alpha (TGF-alpha) is produced by and required for the growth of epithelial cells and is angiogenic in vivo. Since epidermal hyperplasia and angiogenesis are hallmarks of psoriasis, TGF-alpha gene expression was analyzed in epidermal biopsies of normal and psoriatic skin. TGF-alpha messenger RNA and protein are much more abundant in lesional psoriatic epidermis than in normal-appearing skin of psoriatic patients or in normal epidermis. In contrast, messenger RNA levels of transforming growth factor beta 1 (TGF-beta 1), which inhibits epithelial cell growth, are not significantly different in normal, uninvolved, and lesional psoriatic epidermis. Thus, psoriatic epidermal hyperplasia may involve increased expression of a keratinocyte mitogen (TGF-alpha) rather than deficient expression of a growth inhibitor (TGF-beta 1).Keywords
This publication has 35 references indexed in Scilit:
- Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic CellsScience, 1988
- The Koebner phenomenon and the microbial basis of psoriasisJournal of the American Academy of Dermatology, 1988
- Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factorCell, 1987
- Angiogenesis and the skinJournal of the American Academy of Dermatology, 1987
- Decreased Protein Kinase C Activity in Psoriatic Versus Normal EpidermisJournal of Investigative Dermatology, 1987
- Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanismsCell, 1986
- Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in PsoriasisJournal of Investigative Dermatology, 1986
- Cell Kinetic Basis for Pathophysiology of PsoriasisJournal of Investigative Dermatology, 1985
- Evidence for an Alternative Pathway of Keratinocyte Maturation in Psoriasis from an Antigen Found in Psoriatic but Not Normal EpidermisJournal of Investigative Dermatology, 1984
- The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidaseJournal of Ultrastructure Research, 1973