High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
- 1 March 2011
- journal article
- Published by The Journal of Rheumatology in The Journal of Rheumatology
- Vol. 38 (6), 979-982
- https://doi.org/10.3899/jrheum.101261
Abstract
Objective.To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases.Methods.A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease.Results.Male sex (OR 3.29, 95% CI 1.59–6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25–1.78) were identified as independent risk factors for lung disease in the RA population.Conclusion.High anti-CCP2 levels are associated with lung disease in the RA population.This publication has 15 references indexed in Scilit:
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