Thiazide Treatment for Calcium Urolithiasis in Patients with Idiopathic Hypercalciuria
- 1 June 1992
- journal article
- clinical trial
- Published by Wiley in British Journal of Urology
- Vol. 69 (6), 571-576
- https://doi.org/10.1111/j.1464-410x.1992.tb15624.x
Abstract
Summary— In a randomised trial based on a parallel design to determine the prophylactic effect of thiazide on stone formation, 210 calcium urolithiasis patients with idiopathic hypercalciuria were allocated either to treatment with trichlormethiazide (4 mg/day) or no treatment with only close follow‐up; 35 patients were excluded for various reasons, including voluntary withdrawal. The background of the remaining 175 patients (82 in the thiazide group and 93 in the control group), including age and sex, was similar for both groups. In patients treated with thiazide there was a statistically significant fall in urinary calcium output. Statistical analyses also demonstrated that the stone formation rate in the thiazide group was significantly less than that in the control group. Adverse clinical reactions probably due to the drug were observed in 9 patients. These findings indicate that trichlormethiazide has a prophylactic effect on calcium urolithiasis in patients with idiopathic hypercalciuria.Keywords
This publication has 23 references indexed in Scilit:
- Crossover and Self-Controlled Designs in Clinical ResearchNew England Journal of Medicine, 1984
- Designs for Experiments — Parallel Comparisons of TreatmentNew England Journal of Medicine, 1983
- Is selective therapy of recurrent nephrolithiasis possible?American Journal Of Medicine, 1981
- DO THIAZIDES PREVENT RECURRENT IDIOPATHIC RENAL CALCIUM STONES?The Lancet, 1981
- Effects of Therapy with Bendroflumethiazide in Patients with Recurrent Renal Calcium StonesBritish Journal of Urology, 1979
- Prevention of calcium stones with thiazidesKidney International, 1978
- DETERIORATION OF GLUCOSE TOLERANCE IN HYPERTENSIVE PATIENTS ON PROLONGED DIURETIC TREATMENTThe Lancet, 1976
- The Hypercalciurias CAUSES, PARATHYROID FUNCTIONS, AND DIAGNOSTIC CRITERIAJCI Insight, 1974
- Evidence for Secondary Hyperparathyroidism in Idiopathic HypercalciuriaJCI Insight, 1973
- Potentiometric determination of serum ionized calcium in a normal human populationClinica Chimica Acta; International Journal of Clinical Chemistry, 1972