Lyso-PAF Analogues and Lysophosphatidylcholines from the Marine Sponge Spirastrella abata as Inhibitors of Cholesterol Biosynthesis
- 30 September 1999
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (11), 1554-1557
- https://doi.org/10.1021/np990303a
Abstract
A series of phospholipids, including previously undescribed compounds 4−7, were isolated by a bioactivity-guided fractionation from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis in human liver cells. These compounds were identified as lyso-PAF analogues (1−5) and lysophosphatidylcholines (6, 7) based on NMR and MS analyses. Compounds 1−7 specifically blocked the conversion of lanosterol into cholesterol in the Chang liver cell.Keywords
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