Tumor treating fields: a new frontier in cancer therapy
Top Cited Papers
- 9 May 2013
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1291 (1), 86-95
- https://doi.org/10.1111/nyas.12112
Abstract
Tumor treating fields (TTFields) is a noninvasive, regional antimitotic treatment modality that has been approved for the treatment of recurrent glioblastoma by the U.S. FDA and has a CE mark in Europe. TTFields therapy delivers low-intensity (1-3 V/cm), intermediate-frequency (100-300 kHz), alternating electric fields to the tumor using transducer arrays placed on the skin around the region of the body containing the tumor. TTFields therapy affects metaphase, by disrupting mitotic spindle formation, and anaphase, by dielectrophoretic dislocation of intracellular constituents, resulting in apoptosis. TTFields therapy is frequency tuned to specific cancer cell types. The antimitotic effect of TTFields therapy has been demonstrated in multiple cell lines when the appropriate frequency was utilized. A phase III trial of TTFields monotherapy compared to active chemotherapy in recurrent glioblastoma patients established that TTFields therapy is associated with minimal toxicity, better quality of life, and comparable efficacy to chemotherapy. Ongoing and future trials will evaluate TTFields in newly diagnosed glioblastoma, solid tumor brain metastases, nonsmall cell lung cancer, and ovarian and pancreatic cancers.Keywords
This publication has 28 references indexed in Scilit:
- NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modalityEuropean Journal Of Cancer, 2012
- TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transportersBMC Cancer, 2010
- Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungsClinical & Experimental Metastasis, 2009
- Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields)BMC Medical Physics, 2009
- A Pilot Study with Very Low-Intensity, Intermediate-Frequency Electric Fields in Patients with Locally Advanced and/or Metastatic Solid TumorsOnkologie, 2008
- Disruption of Cancer Cell Replication by Alternating Electric FieldsCancer Research, 2004
- Membrane potential induced by external electric field pulses can be followed with a potentiometric dyeBiophysical Journal, 1987
- The strength‐duration relationship for excitation of myelinated nerve: computed dependence on membrane parameters.The Journal of Physiology, 1983
- Changes in fraction of current penetrating an axon as a function of duration of stimulating pulseJournal of Theoretical Biology, 1973
- Stimulation of internal organs by means of externally applied electrodes.Journal of Applied Physiology, 1966