Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: mode of its action
Open Access
- 27 June 2017
- journal article
- Published by American Society of Hematology in Blood Advances
- Vol. 1 (15), 1206-1214
- https://doi.org/10.1182/bloodadvances.2016004143
Abstract
Key PointsEPCR levels influence the hemostatic effect of rFVIIa in hemophilia therapy. FVIIa binding to EPCR influences the hemostatic effect of FVIIa because of downregulation of protein C anticoagulation pathway.Keywords
This publication has 35 references indexed in Scilit:
- Recombinant activated factor VII: 30 years of research and innovationBlood Reviews, 2015
- Endothelial cell protein C receptor: a multiliganded and multifunctional receptorBlood, 2014
- Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systemsThrombosis and Haemostasis, 2012
- Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activityJournal of Thrombosis and Haemostasis, 2007
- Endothelial Cell Protein C Receptor Acts as a Cellular Receptor for Factor VIIa on EndotheliumPublished by Elsevier BV ,2007
- Multifunctional Specificity of the Protein C/Activated Protein C Gla DomainJournal of Biological Chemistry, 2006
- Mechanism of action, development and clinical experience of recombinant FVIIaJournal of Biotechnology, 2006
- The Endothelial Cell Protein C ReceptorThrombosis and Haemostasis, 2000
- The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.Proceedings of the National Academy of Sciences of the United States of America, 1996
- The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”Thrombosis and Haemostasis, 1995