Sickle cell disease: old discoveries, new concepts, and future promise
Top Cited Papers
Open Access
- 2 April 2007
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 117 (4), 850-858
- https://doi.org/10.1172/jci30920
Abstract
The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.This publication has 144 references indexed in Scilit:
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