Anorexia Nervosa and the Immune System—A Narrative Review
Open Access
- 8 November 2019
- journal article
- review article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 8 (11), 1915
- https://doi.org/10.3390/jcm8111915
Abstract
The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervosa, one becomes increasingly suspicious of the immune system’s potential role in the pathophysiology of anorexia nervosa. Specifically, research is suggestive of increased levels of various pro-inflammatory cytokines as well as the spontaneous production of tumor necrosis factor in anorexia nervosa; genetic studies further support a dysregulated immune system in this disorder. Potential contributors to this dysregulated immune system are discussed including increased oxidative stress, chronic physiological/psychological stress, changes in the intestinal microbiota, and an abnormal bone marrow microenvironment, all of which are present in anorexia nervosa.This publication has 194 references indexed in Scilit:
- Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell DifferentiationNutrients, 2013
- How mesenchymal stem cells interact with tissue immune responsesTrends in Immunology, 2012
- Cell signalling by reactive lipid species: new concepts and molecular mechanismsBiochemical Journal, 2012
- Mucin dynamics and enteric pathogensNature Reviews Microbiology, 2011
- Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheNature, 2010
- Innate immunityJournal of Allergy and Clinical Immunology, 2010
- Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43Nature, 2009
- Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironmentNature, 2009
- A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB SignalingBiological Psychiatry, 2008
- Psychological States and Lymphocyte β-Adrenergic Receptor ResponsivenessNeuropsychopharmacology, 1999