Management of small cell carcinoma of the lung.Therapy, staging, and biochemical markers
- 1 September 1976
- Vol. 38 (3), 1394-1401
- https://doi.org/10.1002/1097-0142(197609)38:3<1394::aid-cncr2820380345>3.0.co;2-0
Abstract
A chemotherapeutic regimen consisting of BCNU, cyclophosphamide, vincristine, and procarbazine was evaluated in 43 patients with small cell carcinoma of the lung. The majority of patients received radiation therapy to the primary tumor, but chemotherapy alone was utilized in a group of patients with widely disseminated disease. In addition to thorough staging with radioisotope scans and bone marrow biopsies, a study of calcitonin and histaminase as biochemical markers was performed. The BCVP chemotherapy resulted in a complete and partial response rate of 53% when given alone or in conjunction with radiotherapy. The survival data are preliminary, but the complete responders do have a statistically significant better survival (mean of +295 days) than the partial responders and nonresponders. Hypercalcitonemia was not detected in our patients, but elevated histaminase activity was found in eight of 24 patients with small cell carcinoma and in only one of 19 patients with squamous and large cell carcinoma.This publication has 22 references indexed in Scilit:
- HETEROGENEITY OF CALCITONINThe Lancet, 1975
- Small cell carcinoma of the lung: Staging, paraneoplastic syndromes, treatment, and survivalCancer, 1974
- ECTOPIC PRODUCTION OF CALCITONINThe Lancet, 1973
- MEDICAL RESEARCH COUNCIL COMPARATIVE TRIAL OF SURGERY AND RADIOTHERAPY FOR PRIMARY TREATMENT OF SMALL-CELLED OR OAT-CELLED CARCINOMA OF BRONCHUSThe Lancet, 1973
- Staging of inoperable patients with bronchogenic carcinoma with special reference to bone marrow examination and peritoneoscopyCancer, 1972
- The necropsy findings in carcinoma of the bronchusRespiratory Medicine, 1971
- FIVE-YEAR FOLLOW-UP OF THE MEDICAL RESEARCH COUNCIL COMPARATIVE TRIAL OF SURGERY AND RADIOTHERAPY FOR THE PRIMARY TREATMENT OF SMALL-CELLED OR OAT-CELLED CARCINOMA OF THE BRONCHUS: A REPORT TO THE MEDICAL RESEARCH COUNCIL WORKING PARTY ON THE EVALUATION OF DIFFERENT METHODS OF THERAPY IN CARCINOMA OF THE BRONCHUSThe Lancet, 1969
- A RADIOIMMUNOASSAY FOR HUMAN CALCITONIN MThe Lancet, 1969
- THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPTJournal of Histochemistry & Cytochemistry, 1969
- Maximum utilization of the life table method in analyzing survivalJournal of Chronic Diseases, 1958