Coinfection with Herpes Simplex Virus Type 2 Is Associated with Reduced HIV‐Specific T Cell Responses and Systemic Immune Activation
Open Access
- 15 May 2008
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 197 (10), 1394-1401
- https://doi.org/10.1086/587697
Abstract
Background. Vicriviroc is a C-C motif chemokine receptor 5 (CCR5) antagonist that is in clinical development for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. This study explored the molecular basis for the development of phenotypically resistant virus.Keywords
This publication has 47 references indexed in Scilit:
- Synergistic Copathogens — HIV-1 and HSV-2New England Journal of Medicine, 2007
- Reduction of HIV-1 RNA Levels with Therapy to Suppress Herpes Simplex VirusNew England Journal of Medicine, 2007
- Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studiesAIDS, 2006
- Monthly Antibiotic Chemoprophylaxis and Incidence of Sexually Transmitted Infections and HIV-1 Infection in Kenyan Sex WorkersJAMA, 2004
- The Effects of Herpes Simplex Virus-2 on HIV-1 Acquisition and Transmission: A Review of Two Overlapping EpidemicsJAIDS Journal of Acquired Immune Deficiency Syndromes, 2004
- Determinants of HIV‐1 Load in Subjects with Early and Later HIV Infections, in a General‐Population Cohort of Rakai, UgandaThe Journal of Infectious Diseases, 2004
- How Does Herpes Simplex Virus Type 2 Influence Human Immunodeficiency Virus Infection and Pathogenesis?The Journal of Infectious Diseases, 2003
- Changes in Plasma Human Immunodeficiency Virus Type 1 RNA Associated with Herpes Simplex Virus Reactivation and SuppressionThe Journal of Infectious Diseases, 2002
- The Impact of Active Herpes Simplex Virus Infection on Human Immunodeficiency Virus LoadThe Journal of Infectious Diseases, 1997
- The efficacy and safety of zidovudine alone or as cotherapy with acyclovir for the treatment of patients with AIDS and AIDS-related complexAIDS, 1993