Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study
- 1 March 2006
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 23 (5), 675-680
- https://doi.org/10.1111/j.1365-2036.2006.02773.x
Abstract
A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility. To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying. In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx-A133U, Btx-A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks. Fourteen patients completed the study. The botulinum toxin A-treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite. This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.Keywords
This publication has 18 references indexed in Scilit:
- Mechanism of action of botulinum toxin on the internal anal sphincterBritish Journal of Surgery, 2003
- Botulinum toxin in the therapy of gastrointestinal motility disordersAlimentary Pharmacology & Therapeutics, 2003
- Botulinum toxin injected in the gastric wall reduces body weight and food intake in ratsAlimentary Pharmacology & Therapeutics, 2000
- Are There Changes in Gastric Emptying during the Menstrual Cycle?Scandinavian Journal of Gastroenterology, 1999
- A Comparison of Botulinum Toxin and Saline for the Treatment of Chronic Anal FissureThe New England Journal of Medicine, 1998
- Neurochemical coding of enteric neurons in the guinea pig stomachJournal of Comparative Neurology, 1995
- Botulinum toxin for chronic anal fissureThe Lancet, 1994
- Tetanus and Botulinum Neurotoxins Are Zinc Proteases Specific for Components of the Neuroexocytosis ApparatusaAnnals of the New York Academy of Sciences, 1994
- Selective location of acceptors for botulinum neurotoxin a in the central and peripheral nervous systemsNeuroscience, 1987
- Effect of the Menstrual Cycle on Gastric EmptyingDigestion, 1987