Polarization-sensitive optical coherence tomography for imaging human atherosclerosis
- 9 April 2007
- journal article
- research article
- Published by Optica Publishing Group in Applied Optics
- Vol. 46 (13), 2520-2527
- https://doi.org/10.1364/ao.46.002520
Abstract
Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.Keywords
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