Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes
- 1 March 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 47 (3), 439-450
- https://doi.org/10.1007/s00125-003-1315-1
Abstract
Preproinsulin is a target T cell autoantigen in human Type 1 diabetes. This study analyses the phenotype and epitope recognition of preproinsulin reactive T cells in subjects with a high genetic risk of diabetes [HLA-DRB1*04, DQ8 with Ab+ (autoantibody-positive) or without islet autoantibodies (control subjects)], and in HLA-matched diabetic patients.Keywords
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