Wnt Signaling in Cancer Stem Cell Biology
Open Access
- 27 June 2016
- Vol. 8 (7), 60
- https://doi.org/10.3390/cancers8070060
Abstract
Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations that result in elevated Wnt pathway activity. More recently, it has become apparent that Wnt signaling levels identify stem-like tumor cells that are responsible for fueling tumor growth. As therapeutic targeting of these tumor stem cells is an intense area of investigation, a concise understanding on how Wnt activity relates to cancer stem cell traits is needed. This review attempts at summarizing the intricacies between Wnt signaling and cancer stem cell biology with a special emphasis on colorectal cancer.Keywords
Funding Information
- European Research Council (638193)
- KWF Kankerbestrijding (UVA2014-7245)
- Worldwide Cancer Research (14-1164)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Vidi 016.156.308)
- Dutch Digestive foundation (MLDS-CDG 14-03)
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