Socially induced morphine pseudosensitization in adolescent mice
- 1 March 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Behavioural Pharmacology
- Vol. 21 (2), 112-120
- https://doi.org/10.1097/fbp.0b013e328337be25
Abstract
Given that social influences are among the strongest predictors of adolescents' drug use, this study examined the effect of social interaction on morphine-induced hyperlocomotion in both adolescent and adult mice. Three experimental groups of adolescent and adult male mice were examined (i) morphine-treated mice (twice daily, 10–40 mg/kg, subcutaneous), (ii) saline-injected mice housed together with the morphine-treated mice (‘saline cage-mates’), and (iii) saline-injected mice housed physically and visually separated from the morphine-treated mice (‘saline alone’). After the treatment period, mice were tested individually for their locomotor response to 10 mg/kg morphine (subcutaneous). Adolescent saline cage-mates, though administered morphine for the very first time, exhibited an enhanced hyperlocomotion response similar to the locomotor sensitization response exhibited by the morphine-treated mice. This was not observed in adults. In adults, there were no significant differences in morphine-induced hyperlocomotion between saline alone and saline cage-mates. As expected, morphine-treated adults and adolescents both exhibited locomotor sensitization. These results show a vulnerability to social influences in adolescent mice, which does not exist in adult mice.Keywords
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