Pharmaceutical Analysis for Environmental Samples: Individual and Simultaneous Determination of Ciprofloxacin, Ofloxacin and Norfloxacin Using an HPLC with Fluorescence and UV Detection with a Wetland Soil Matrix
- 10 November 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Analytical Letters
- Vol. 42 (18), 2937-2950
- https://doi.org/10.1080/00032710903201883
Abstract
Two HPLC methods were developed for individual and simultaneous determination of ciprofloxacin, norfloxacin and ofloxacin for use in laboratory experiments producing large numbers of samples (100 s to 1000 s). Individual compound detection produced retention times between 1.5 and 2 min and simultaneous detection between 6.5 to 8 min. The methods are compatible with complex geomatrices, e.g. a wetland soil. These methods provide 1) detection limits in the low parts per-billion range; 2) decrease in retention times of 5–10 times for single compounds, and up to 2 times for simultaneous detection over published methods; and 3) require no solid phase extraction.Keywords
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