Preparation and Evaluation of Uniform-Sized Sol–Gel Theophylline Imprinted Microspheres as Solid Phase Extraction Sorbent
- 28 September 2010
- journal article
- preconcentration techniques
- Published by Taylor & Francis Ltd in Analytical Letters
- Vol. 43 (15), 2318-2330
- https://doi.org/10.1080/00032711003717364
Abstract
A highly selective imprinted amino-functionalized silica gel microsphere was prepared by a simple molecular imprinting technique with a sol–gel process. Theophylline was used as template; 3-aminopropyltrimethoxysilane (APTMS) as functional monomer and tetraethylorthosilicate (TEOS) as reticulating agent. These theophylline imprinted silica microspheres were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron micrographs (SEM), thermogravimetric analysis (TGA), and high performance liquid chromatography (HPLC) in detail. The results showed that monodispersive APTMS-silica imprinted microspheres with size of 250 nm were synthesized successfully. Two kind of binding sites exist between the sol–gel imprinted microspheres and theophylline with K D and Q max for the higher affinity binding parameters was 1.89 μg/mL and 7.47 μg/mg dry polymers, and for the lower affinity binding sites were found to be 0.18 μg/mL and 3.47 μg/mg dry polymers, respectively. Packed in column, the imprinted microspheres were employed to extract theophylline from green tea successfully.Keywords
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