Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
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- 25 October 2007
- journal article
- review article
- Published by Taylor & Francis Ltd in Critical Reviews in Food Science and Nutrition
- Vol. 47 (8), 735-748
- https://doi.org/10.1080/10408390601062054
Abstract
Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas, enhances the digestive capacity and significantly reduces the gastrointestinal food transit time. Piperine has been demonstrated in in vitro studies to protect against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species. Black pepper or piperine treatment has also been evidenced to lower lipid peroxidation in vivo and beneficially influence cellular thiol status, antioxidant molecules and antioxidant enzymes in a number of experimental situations of oxidative stress. The most far-reaching attribute of piperine has been its inhibitory influence on enzymatic drug biotransforming reactions in the liver. It strongly inhibits hepatic and intestinal aryl hydrocarbon hydroxylase and UDP-glucuronyl transferase. Piperine has been documented to enhance the bioavailability of a number of therapeutic drugs as well as phytochemicals by this very property. Piperine's bioavailability enhancing property is also partly attributed to increased absorption as a result of its effect on the ultrastructure of intestinal brush border. Although initially there were a few controversial reports regarding its safety as a food additive, such evidence has been questionable, and later studies have established the safety of black pepper or its active principle, piperine, in several animal studies. Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences.Keywords
This publication has 63 references indexed in Scilit:
- Characterization of a new rat urinary metabolite of piperine by LC/NMR/MS studiesEuropean Journal of Pharmaceutical Sciences, 2003
- Piperine Inhibits Gastric Emptying and Gastrointestinal Transit in Rats and MicePlanta Medica, 2001
- Antidiarrhoeal Activity of Piperine in MicePlanta Medica, 2001
- Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementationThe Journal of Nutritional Biochemistry, 2000
- Piperine, a plant alkaloid of the piper species, enhances the bioavailability of aflatoxin B1 in rat tissuesCancer Letters, 1992
- Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteersEuropean Journal of Clinical Pharmacology, 1991
- Studies on the metabolism of piperine: Absorption, tissue distribution and excretion of urinary conjugates in ratsToxicology, 1986
- LACK OF ADVERSE INFLUENCE OF BLACK PEPPER, ITS OLEORESIN AND PIPERINE IN THE WEANLING RATJournal of Food Safety, 1986
- Dietary Carcinogens and AnticarcinogensScience, 1983
- Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugsJournal of Ethnopharmacology, 1981