Amyloidosis of the Upper Aerodigestive Tract
- 1 December 2003
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 113 (12), 2095-2101
- https://doi.org/10.1097/00005537-200312000-00007
Abstract
Objectives/Hypothesis To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis. Study Design Retrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals. Material and Methods The charts of 16 patients with upper aerodigestive tract amyloidosis identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study. Results Sixteen patients (9 male and 7 female, with an average age of 49.8 years) with upper aerodigestive tract amyloidosis were identified. The most common site of amyloid involvement was the larynx. Consequently, patients most commonly presented with hoarseness (14 of 16). All patients underwent surgical removal of the amyloid deposits. Fourteen patients had primary localized amyloidosis. Two experienced systemic involvement. Seven of the 16 patients developed recurrences requiring further treatment. Conclusions Amyloidosis of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow-up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.Keywords
This publication has 30 references indexed in Scilit:
- Amyloidosis of the Larynx: A Clinicopathologic Study of 11 CasesLaboratory Investigation, 2000
- Parti Nomenclature of amyloid fibril proteins: Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9,1998Amyloid, 1999
- Imaging amyloidosis with radiolabelled SAPEuropean Journal of Nuclear Medicine and Molecular Imaging, 1995
- Beta‐2‐microglobulin as the main component of primary amyloidosis located in the larynxThe Laryngoscope, 1989
- Amyloid deposits in the aged tongue: a postmortem study of 107 individuals over 60 years of ageJournal of Oral Pathology & Medicine, 1982
- Amyloid Deposits and AmyloidosisThe New England Journal of Medicine, 1980
- Amyloid Deposits and AmyloidosisThe New England Journal of Medicine, 1980
- Amyloid in localised deposits and plasmacytomas of the respiratory tractThe Journal of Pathology, 1979
- Amyloidosis of the LarynxActa Oto-Laryngologica, 1979
- Primary Amyloidosis: A ReviewJournal of Clinical Pathology, 1956