Transcription of DNA injected into Xenopus oocytes is influenced by template topology
- 1 March 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 302 (5903), 38-43
- https://doi.org/10.1038/302038a0
Abstract
We have assayed the transcription of the herpes simplex virus thymidine kinase gene on circular and linear plasmids after injection into Xenopus oocytes. The circular plasmids appear to be transcribed at least 500 times more efficiently than the linear plasmids. Moreover, when the circular templates are allowed to form functioning transcription complexes, and are then linearized in situ, the synthesis of accurate transcripts is substantially reduced.This publication has 30 references indexed in Scilit:
- Left-handed Z-DNA is induced by supercoiling in physiological ionic conditionsNature, 1982
- Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.Proceedings of the National Academy of Sciences of the United States of America, 1982
- The path of DNA in the nucleosomeCell, 1982
- An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatinCell, 1982
- Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomesNature, 1981
- DNA TopoisomerasesAnnual Review of Biochemistry, 1981
- Polyoma DNA sequences involved in control of viral gene expression in murine embryonal carcinoma cellsNature, 1981
- Cruciform structures in supercoiled DNANature, 1981
- The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.Proceedings of the National Academy of Sciences of the United States of America, 1980
- Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogasterCell, 1976