Highly Enantioselective and Organocatalytic α-Amination of 2-Oxindoles
- 5 August 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (17), 3874-3877
- https://doi.org/10.1021/ol901405r
Abstract
An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N-unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids In good to excellent yields with high enantioselectivities.This publication has 46 references indexed in Scilit:
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