Functional maturation of adult‐generated granule cells
- 12 January 2006
- journal article
- review article
- Published by Wiley in Hippocampus
- Vol. 16 (3), 208-215
- https://doi.org/10.1002/hipo.20152
Abstract
The excitability and connectivity of adult‐generated granule cells dictate to what extent newborn neurons participate in the hippocampal network. These functional parameters evolve as newborn cells mature and interact with the existing circuit. The progression of granule cell maturation during neonatal development appears to be reiterated in the adult, but with some caveats. New approaches to identify and track newborn neurons are revealing the timing of this process, as well as its sensitivity to activity‐dependent regulation.Keywords
This publication has 48 references indexed in Scilit:
- GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor CellsNeuron, 2005
- Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle CellsPhysiological Reviews, 2005
- AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cellsDevelopmental Brain Research, 2005
- Milestones of neuronal development in the adult hippocampusTrends in Neurosciences, 2004
- A Transgenic Marker for Newly Born Granule Cells in Dentate GyrusJournal of Neuroscience, 2004
- Is there more to gaba than synaptic inhibition?Nature Reviews Neuroscience, 2002
- Astroglia induce neurogenesis from adult neural stem cellsNature, 2002
- Liquid junction potentials and small cell effects in patch-clamp analysisThe Journal of Membrane Biology, 1991
- An autoradiographic study of the development of the entorhinal and commissural afferents to the dentate gyrus of the RatJournal of Comparative Neurology, 1977
- An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the ratJournal of Comparative Neurology, 1975