Directional sensing in eukaryotic chemotaxis: A balanced inactivation model
- 27 June 2006
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 103 (26), 9761-9766
- https://doi.org/10.1073/pnas.0601302103
Abstract
Many eukaryotic cells, including Dictyostelium discoideum amoebae, fibroblasts, and neutrophils, are able to respond to chemoattractant gradients with high sensitivity. Recent studies have demonstrated that, after the introduction of a chemoattractant gradient, several chemotaxis pathway components exhibit a subcellular reorganization that cannot be described as a simple amplification of the external gradient. Instead, this reorganization has the characteristics of a switch, leading to a well defined front and back. Here, we propose a directional sensing mechanism in which two second messengers are produced at equal rates. The diffusion of one of them, coupled with an inactivation scheme, ensures a switch-like response to external gradients for a large range of gradient steepness and average concentration. Furthermore, our model is able to reverse the subcellular organization rapidly, and its response to multiple simultaneous chemoattractant sources is in good agreement with recent experimental results. Finally, we propose that the dynamics of a heterotrimeric G protein might allow for a specific biochemical realization of our model.Keywords
This publication has 41 references indexed in Scilit:
- Membrane-bound Turing patternsPhysical Review E, 2005
- A mechanistic model for eukaryotic gradient sensing: Spontaneous and induced phosphoinositide polarizationJournal of Theoretical Biology, 2004
- CHEMOATTRACTANT SIGNALING IN DICTYOSTELIUM DISCOIDEUMAnnual Review of Cell and Developmental Biology, 2004
- Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patchesJournal of Cell Science, 2004
- Gα-Mediated Inhibition of Developmental Signal ResponseCurrent Biology, 2002
- Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated deviceNature Biotechnology, 2002
- Tumor Suppressor PTEN Mediates Sensing of Chemoattractant GradientsCell, 2002
- A Cell's Sense of DirectionScience, 1999
- G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALSAnnual Review of Biochemistry, 1987
- The chemical basis of morphogenesisPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1952