Challenges in diagnosis of pancreatic cancer
Top Cited Papers
Open Access
- 21 May 2018
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 24 (19), 2047-2060
- https://doi.org/10.3748/wjg.v24.i19.2047
Abstract
Pancreatic cancer is a growing source of cancer related death, yet has poor survival rates which have not improved in the last few decades. Its high mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis and the lack of standardised international guidelines in assessing suspicious pancreatic masses. This review aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of available diagnostic technology. The main modalities discussed are imaging with computed tomography, magnetic resonance imaging, endoscopic ultrasound and positron emission tomography and tissue acquisition with fine needle aspiration. We also review the improvements in the techniques used for tissue acquisition and the opportunity for personalised cancer medicine. Screening of high risk individuals, promising biomarkers and common mimickers of pancreatic cancer are also explored, as well as suggestions for future research directions to allow for earlier detection of pancreatic cancer. Timely and accurate diagnosis of pancreatic cancer can lead to improvements in the current poor outcome of this disease.Keywords
This publication has 96 references indexed in Scilit:
- Use of EUS-FNA in diagnosing pancreatic neoplasm without a definitive mass on CTGastrointestinal Endoscopy, 2013
- Randomized trial comparing fanning with standard technique for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic mass lesionsEndoscopy, 2013
- International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancerGut, 2012
- Multimodality Imaging of Pancreatic Cancer—Computed Tomography, Magnetic Resonance Imaging, and Positron Emission TomographyThe Cancer Journal, 2012
- Imaging of Pancreatic Adenocarcinoma: Update on Staging/ResectabilityRadiologic Clinics of North America, 2012
- EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysisGastrointestinal Endoscopy, 2012
- 18F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancerWorld Journal of Gastroenterology, 2011
- Review of screening for pancreatic cancer in high risk individualsWorld Journal of Gastroenterology, 2011
- EUS-FNA is more advantageous than ERCP in tissue sampling for pathological diagnosis of pancreatic cancerGastrointestinal Endoscopy, 2009
- The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancerEuropean Journal of Surgical Oncology, 2005