Noninvasive measurement of total hemoglobin and hemoglobin derivatives using multiwavelength pulse spectrophotometry -In vitro study with a mock circulatory system
- 1 August 2006
- conference paper
- research article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- Vol. 2006 (1557170X), 799-802
- https://doi.org/10.1109/iembs.2006.260273
Abstract
Total hemoglobin (tHb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) are usually measured with a CO-oximeter. Noninvasive and continuous measurement of these blood components is expected to decrease the pain of a patient. Therefore, we developed an instrument to measure oxygen saturation (SpO2), tHb, COHb, and MetHb non invasively. Multiwavelength LED (600, 625, 660, 760, 800, 940, and 1300 nm) and a combined detector (Si, InGaAs) were built into the instrument (Seven wavelengths transparent pulse spectrophotometer). We used the Waseda mock circulatory system, which can simulate blood circulation in tissues and generate a pulse wave mechanically, to estimate the instrument's performance. Furthermore we proposed new calculation formula including DC components of optical density (this method). Under conditions without any change of other components, the mean error plusmn standard deviation between this method and the CO-oximetry were SaO2=0.0plusmn1.4%, tHb=0.0plusmn0.0 g/dl, COHb=0.0plusmn2.0%, and MetHb=0.0plusmn0.3%. When the concentration of other components was changed, this method showed mean errors and standard deviations of SaO2=0.2plusmn1.6%, tHb=0.0plusmn0.4 g/dl, COHb=0.5plusmn4.1%, and MetHb=0.0plusmn0.3%Keywords
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