Pneumococcal polysaccharide vaccination for adults: new perspectives for Europe
- 1 August 2011
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Vaccines
- Vol. 10 (8), 1143-1167
- https://doi.org/10.1586/erv.11.99
Abstract
Vaccination is the only public-health measure likely to reduce the burden of pneumococcal diseases. In 2010, a group of European experts reviewed evidence on the burden of pneumococcal disease and the immunogenicity, clinical effectiveness and cost-effectiveness of vaccination with 23-valent pneumococcal polysaccharide vaccine (PPV23). They also considered issues affecting the future use of PPV23 and pneumococcal conjugate vaccines in the elderly and adults at high risk of pneumococcal disease. PPV23 covers 80-90% of the serotypes responsible for invasive pneumococcal disease in Europe. Primary vaccination and revaccination with PPV23 are well tolerated, induce robust, long-lasting immune responses in elderly adults and are cost effective. Ensuring protection against pneumococcal disease requires monitoring of the changing epidemiology of pneumococcal serotypes causing invasive pneumococcal disease and improving vaccine coverage. In the future, it will be critically important for pneumococcal vaccination recommendations for elderly adults to be based on comparative evaluations of PPV23 and newer pneumococcal conjugate vaccines with regard to their long-term immunogenicity, clinical effectiveness and cost-effectiveness.Keywords
This publication has 101 references indexed in Scilit:
- Rapid Pneumococcal Evolution in Response to Clinical InterventionsScience, 2011
- Serotype-Specific Hyporesponsiveness to Pneumococcal Conjugate Vaccine in Infants Carrying Pneumococcus at the Time of VaccinationThe Journal of Pediatrics, 2010
- Cost-effectiveness of dual influenza and pneumococcal vaccination in 50-year-oldsVaccine, 2010
- Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta‐AnalysisClinical Infectious Diseases, 2010
- Association of Serotypes of Streptococcus pneumoniae with Age in Invasive Pneumococcal DiseaseJournal of Clinical Microbiology, 2010
- Trends in invasive pneumococcal disease among older adults in Olmsted County, MinnesotaJournal of Infection, 2009
- Superior Immune Response to Protein-Conjugate versus Free Pneumococcal Polysaccharide Vaccine in Chronic Obstructive Pulmonary DiseaseAmerican Journal of Respiratory and Critical Care Medicine, 2009
- Invasive Pneumococcal Disease among Adults: Associations among Serotypes, Disease Characteristics, and OutcomeClinical Infectious Diseases, 2009
- Immunological responses to pneumococcal vaccine in frail older peopleVaccine, 2009
- Initial and Subsequent Response to Pneumococcal Polysaccharide and Protein‐Conjugate Vaccines Administered Sequentially to Adults Who Have Recovered from Pneumococcal PneumoniaThe Journal of Infectious Diseases, 2008