Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation
- 1 May 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Origins of Life and Evolution of Biospheres
- Vol. 21 (3), 165-176
- https://doi.org/10.1007/bf01809445
Abstract
The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.Keywords
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