Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
Top Cited Papers
- 18 October 2009
- journal article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 41 (11), 1234-1237
- https://doi.org/10.1038/ng.472
Abstract
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.Keywords
This publication has 28 references indexed in Scilit:
- Review of recent genome‐wide association scans in lupusJournal of Internal Medicine, 2009
- Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studiesNature Reviews Genetics, 2009
- Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong ChineseGenes & Immunity, 2009
- Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathwaysNature Genetics, 2009
- Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAXThe New England Journal of Medicine, 2008
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006
- Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burdenLupus, 2006
- Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East AsiansScience China Life Sciences, 2001
- Genetic relationship of populations in ChinaProceedings of the National Academy of Sciences of the United States of America, 1998
- Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1997