Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer
- 14 June 2016
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 22 (12), 3005-3015
- https://doi.org/10.1158/1078-0432.ccr-15-2762
Abstract
Purpose: CD8+ tumor-infiltrating lymphocytes (TIL) are key mediators of antitumor immunity and are strongly associated with survival in virtually all solid tumors. However, the prognostic effect of CD8+ TIL is markedly higher in the presence of CD20+ B cells, suggesting that cooperative interactions between these lymphocyte subsets lead to more potent antitumor immunity.Keywords
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Funding Information
- Canadian Institutes of Health Research (MOP-137133)
- U.S. Department of Defense (W81XWH-12-1-0604)
- Canadian Cancer Society Research Institute (702497)
- OVCARE & Vancouver General Hospital Foundation and BC Cancer Foundation (Carraressi Foundation Research Grant, 2013))
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