Rituximab therapy for steroid-dependent minimal change nephrotic syndrome
- 1 November 2006
- journal article
- case report
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 21 (11), 1698-1700
- https://doi.org/10.1007/s00467-006-0228-x
Abstract
We present a patient with steroid-sensitive but high-dose steroid-dependent nephrotic syndrome who was treated with rituximab. For 9 months following therapy she had undetectable CD19 cells in the peripheral circulation. She remained in remission during this period even though therapy was reduced to low-dose, alternate day prednisolone only. After 9 months, CD19 cells were once again detectable. Shortly after CD19 cells became detectable again she relapsed. We conclude that B-lymphocytes play a central role in the pathogenesis of idiopathic minimal change nephrotic syndrome (MCNS) and that rituximab may have a useful role in the management of steroid-dependent patients.Keywords
This publication has 17 references indexed in Scilit:
- Mechanisms of Disease: focal segmental glomerulosclerosisNature Clinical Practice Nephrology, 2005
- Rituximab treatment for posttransplant lymphoproliferative disorder (PTLD) induces complete remission of recurrent nephrotic syndromePediatric Nephrology, 2005
- Children with Steroid-sensitive Nephrotic Syndrome Come of Age: Long-term OutcomeThe Journal of Pediatrics, 2005
- Evidence-based management of steroid-sensitive nephrotic syndromePediatric Nephrology, 2005
- T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndromeKidney International, 2005
- Changes of Lymphocyte Populations in Pediatric Steroid-Sensitive Nephrotic Syndrome Are More Pronounced in Remission than in RelapseAmerican Journal of Nephrology, 2005
- Abnormal RNA Processing and Altered Expression of Serin-Rich Proteins in Minimal-Change Nephrotic SyndromePediatric Research, 2005
- Role of the immune system in the pathogenesis of idiopathic nephrotic syndromeClinical Science, 2004
- Combined T- and B-cell activation in childhood steroid-sensitive nephrotic syndromeClinical Nephrology, 2003
- Long-term outcome of primary nephrotic syndrome.Archives of Disease in Childhood, 1982