Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension
- 23 September 2003
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 108 (12), 1493-1498
- https://doi.org/10.1161/01.cir.0000089087.25930.ff
Abstract
Background— Chronic hypoxia–induced pulmonary hypertension is associated with increased pulmonary expression of nitric oxide synthase (NOS) enzymes. Nevertheless, some reports have indicated decreased pulmonary production of NO in the disease. To address this paradox, we determined pulmonary concentrations of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) in the hypoxia-induced pulmonary hypertension rat model. In addition, we determined whether dysregulation of the ADMA-metabolizing enzyme dimethylarginine dimethylaminohydrolase I (DDAH I) plays a role in this disease.Keywords
This publication has 20 references indexed in Scilit:
- all- trans -Retinoic Acid Increases Nitric Oxide Synthesis by Endothelial CellsCirculation Research, 2002
- Inhaled Nitric OxideAnesthesiology, 1999
- l-Arginine Reduces Right Heart Hypertrophy in Hypoxia-Induced Pulmonary HypertensionBiochemical and Biophysical Research Communications, 1999
- Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolaseBritish Journal of Pharmacology, 1996
- Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung.American Journal of Respiratory Cell and Molecular Biology, 1995
- Effect of L-Arginine Infusion on Infants with Persistent Pulmonary Hypertension of the NewbornNeonatology, 1995
- Acute and Prolonged Hypoxia Attenuate Endothelial Nitric Oxide Production in Rat Pulmonary Arteries by Different MechanismsJournal of Cardiovascular Pharmacology, 1993
- Detection of NG, NG-Dimethylarginine Dimethylaminohydrolase in the Nitric Oxide-Generating Systems of Rats Using Monoclonal AntibodyArchives of Biochemistry and Biophysics, 1993
- Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failureThe Lancet, 1992
- Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.JCI Insight, 1991